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KMID : 1007520150240010315
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Food Science and Biotechnology
2015 Volume.24 No. 1 p.315 ~ p.321
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Anti-adipogenic Activity of Blue Mussel (Mytilus edulis) Extract by Regulation of 3T3-L1 Adipogenesis through Wnt/β-catenin Signaling Pathway
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Shon Myung-Soo
Kim Si-Kyung
Song Ji-Hye
Lee Seung-Cheol
Kim Gyo-Nam
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Abstract
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The blue mussel (Mytilus edulis) is widely distributed in European waters but it is little consumed. Although several studies have been reported biological activities of mussels, the anti-adipogenic activity of blue mussel and the molecular mechanism in anti-obese activity remain unknown. Here, we prepared a water extract of blue mussel (BME) and its anti-adipogenic activity was assessed in 3T3-L1 cells. BME treatment dose-dependently inhibited 3T3-L1 lipid accumulation, as judged by Oil Red O staining and microscopic analysis. Consistent with this, BME treatment markedly suppressed mRNA expression levels of adipogenic genes, such as C/EBPβ, PPARγ, C/EBPα, and FAS, in 3T3-L1 mature adipocytes. BME-inhibited lipid accumulation in 3T3-L1 adipocytes was limited with treatment after adipocyte differentiation, particularly in the early and intermediate stages. We also showed that the Wnt/β-catenin signaling pathway is required in BMEinhibited 3T3-L1 adipogenesis. These finding may provide scientific evidence for the development of functional foods against obesity.
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KEYWORD
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Mytilus edulis, mussel, obesity, adipogenesis, Wnt/β-catenin
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